Project Overview

Young people diagnosed with type 1 diabetes are at risk of long-term complications, including kidney and heart disease. AdDIT is studying an observational cohort of youth with type 1 diabetes along with a group of healthy age-matched subjects and longitudinally assessing both kidney function and cardiovascular function. We are measuring biological factors, including urinary biomarkers, psychosocial, and social factors to identify and better understand who is at risk for the development of chronic kidney disease.

We have created an advisory council consisting of patients and their families. This council ensures patients can take part in all aspects of the project and have a strong voice in shaping the research agenda.

AdDIT: Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial

Project lead(s):

Dr. James Scholey, Dr. Farid Mahmud & Dr. Etienne Sochett

Patient lead(s):

Lynne McArthur

Research theme(s):

Diabetes

Project video

Visual Abstract

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Publications

  • Renal Hemodynamic Function and RAAS Activation Over the Natural History of Type 1 Diabetes

    American Journal of Kidney Diseases

    Lytvyn Y, Bjornstad P, Lovshin JA, Boulet G, Farooqi MA, Lai V, Tse J, Cham L, Lovblom LE, Weisman A, Keenan HA, Brent MH, Paul N, Bril V, Advani A, Sochett E, Perkins BA, Cherney DZI

    Research Project: AdDIT

    Keywords: Type 1 diabetes

  • Association between uric acid, renal haemodynamics and arterial stiffness over the natural history of type 1 diabetes

    Diabetes, Obesity & Metabolism

    Lytvyn Y, Bjornstad P, Lovshin JA, Singh SK, Boulet G, Farooqi MA, Lai V, Tse J, Cham L, Lovblom LE, Weisman A, Keenan HA, Brent MH, Paul N, Bril V, Advani A, Sochett E, Perkins BA, Cherney DZI

    Research Project: AdDIT

    Keywords: Type 1 diabetes

  • Peptidomic Analysis of Urine from Youths with Early Type 1 Diabetes Reveals Novel Bioactivity of Uromodulin Peptides In Vitro

    Molecular & Cellular Proteomics

    Van JAD, Clotet-Freixas S, Zhou J, Batruch I, Sun C, Glogauer M, Rampoldi L, Elia Y, Mahmud FH, Sochett E, Diamandis EP, Scholey JW, Konvalinka A

    Research Project: AdDIT

    Keywords: Pediatrics, Type 1 diabetes

  • Urinary proteomics links keratan sulfate degradation and lysosomal enzymes to early type 1 diabetes

    PLoS One

    Van JAD, Clotet-Freixas S, Hauschild AC, Batruch I, Jurisica I, Elia Y, Mahmud FH, Sochett E, Diamandis EP, Scholey JW, Konvalinka A

    Research Project: AdDIT

    Keywords: Type 1 diabetes, Pediatrics

  • Urinary podocyte-derived microparticles in youth with type 1 and type 2 diabetes

    Diabetologia

    Sullivan KM, Scholey J, Moineddin R, Sochett E, Wicklow B, Elia Y, Xiao F, Mederios T, Sadi P, Burger D, Mahmud FH, Dart AB

    Research Project: iCARE,AdDIT

    Keywords: type 2 diabetes, Type 1 diabetes

  • Biomarkers associated with early stages of kidney disease in adolescents with type 1 diabetes

    Pediatric Diabetes

    Marcovecchio ML, Colombo M, Dalton RN, McKeigue PM, Benitez-Aguirre P, Cameron FJ, Chiesa ST, Couper JJ, Craig ME, Daneman D, Davis EA, Deanfield JE, Donaghue KC, Jones TW, Mahmud FH, Marshall SM, Neil A, Colhoun HM, Dunger DB; AdDIT and the SDRNT1BIO Investigators.

    Research Project: AdDIT

    Keywords: Glomerular Filtration Rate, Type 1 diabetes

  • Medication Adherence During Adjunct Therapy With Statins and ACE Inhibitors in Adolescents With Type 1 Diabetes.

    Diabetes Care

    Niechciał E, Acerini CL, Chiesa ST, Stevens T, Dalton RN, Daneman D, Deanfield JE, Jones TW, Mahmud FH, Marshall SM, Neil HAW, Dunger DB, Marcovecchio ML

    Research Project: AdDIT

    Keywords: Type 1 diabetes

  • Vascular Effects of ACE (Angiotensin-Converting Enzyme) Inhibitors and Statins in Adolescents With Type 1 Diabetes

    Hypertension

    Chiesa ST, Marcovecchio ML, Benitez-Aguirre P, Cameron FJ, Craig ME, Couper JJ, Davis EA, Dalton RN, Daneman D, Donaghue KC, Jones TW, Mahmud FH, Marshall SM, Neil HAW, Dunger DB, Deanfield JE

    Research Project: AdDIT

    Keywords: Type 1 diabetes

  • Comparison of Clinical and Social Characteristics of Canadian Youth Living with Type 2 and Type 1 Diabetes

    Canadian Journal of Diabetes

    Carino M, Elia Y, Sellers E, Curtis J, McGavock J, Scholey J, Hamilton J, Clarson C, Pinto T, Hadjiyannakis S, Mertens L, Samaan MC, Ho J, Nour M, Panagiotopoulos C, Jetha M, Gabbs M, Mahmud FH, Wicklow B, Dart A

    Research Project: iCARE,AdDIT

    Keywords: type 2 diabetes, Type 1 diabetes

  • Evaluation of novel glomerular filtration rate estimation equations in adolescents and young adults with type 1 diabetes

    Journal of Diabetes and its Complications

    Gaebe K, White CA, Mahmud FH, Scholey JW, Elia YT, Sochett EB, Cherney DZ

    Research Project: AdDIT

    Keywords: Glomerular Filtration Rate, Type 1 diabetes

  • Relationship between serum inflammatory markers and vascular function in a cohort of adolescents with type 1 diabetes

    Cytokine

    Sochett E, Noone D, Grattan M, Slorach C, Moineddin R, Elia Y, Mahmud FH, Dunger DB, Dalton N, Cherney D, Scholey J, Reich H, Deanfield J.

    Research Project: AdDIT

    Keywords: Diabetes

  • Hyperfiltration, urinary albumin excretion, and ambulatory blood pressure in adolescents with Type 1 diabetes mellitus

    American Journal of Physiology – Renal Physiology

    Lovshin JA, Škrtić M, Bjornstad P, Moineddin R, Daneman D, Dunger D, Reich HN, Mahmud F, Scholey J, Cherney DZI, Sochett E

    Research Project: AdDIT

    Keywords: Diabetes, Cardiovascular Disease

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