Project Overview

The AdDIT (Adolescent Diabetes Cardio-Renal Intervention Trial) and iCARE (Improving Renal Complications in Adolescents with Type 2 Diabetes through Research) studies are working together to identify the most important risk factors for early kidney disease in youth with diabetes. There are important differences in the timing of onset and rates of progression of chronic kidney disease (CKD) in youth with type 1 and type 2 diabetes. Can-SOLVE CKD has provided the opportunity to link two existing projects together so that, guided by our patient partners, we can study a broad range of factors that could both contribute to the risk of CKD, as well as signal high-risk patients that need more intensive treatment. We are measuring biological, psychological and social factors in youth, as well as a panel of biomarkers (markers of inflammation, proteins, hormones and kidney filter micro-particles) in order to broadly address our project goal. This joint project will lead to a better understanding of why kidney injury happens in youth with diabetes, and what can potentially be done to stop or slow down this process in order to decrease the risk of kidney failure in adulthood.

iCARE: Improving renal complications in adolescents with type 2 diabetes through research

Project lead(s):

Dr. Allison Dart and Dr. Brandy Wicklow

Patient lead(s):

Jackie McKee

Research theme(s):

Indigenous Health, Diabetes

Project video

Visual Abstract

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Project Newsletters

Publications

  • Estimating Glomerular Filtration Rate in Youth with Obesity and type 2 diabetes; the iCARE Study Equation

    Pediatric Nephrology

    Dart AB, McGavock J, Sharma A, Chateau D, Schwartz GJ, Blydt-Hansen T

    Research Project: iCARE

    Keywords: type 2 diabetes

  • “A Holistic Approach to Risk for Early Kidney Injury in Indigenous Youth with Type 2 Diabetes; A Proof of Concept Paper from the iCARE Cohort. “

    Canadian Journal of Kidney Health and Disease

    Dart AB, Wicklow B, Blydt-Hansen TD, Sellers EAC, Malik S, Chateau D, Sharma A, McGavock JM

    Research Project: iCARE

    Keywords: Indigenous Health, type 2 diabetes

  • An evaluation of renin-angiotensin system markers in youth with type 2 diabetes and associations with renal outcomes

    Pediatric Diabetes

    Dart AB, Wicklow B, Scholey J, Sellers EA, Dyck J, Mahmud F, Sochett E, Hamilton J, Blydt-Hansen T, Burns K

    Research Project: iCARE

    Keywords: type 2 diabetes

  • Altered DNA Methylation and Serum Levels of Metabolites is Associated With Type 2 Diabetes in Adolescents

    Canadian Journal of Diabetes

    Agarwal P, Dart AB, Wicklow B, et al

    Research Project: iCARE

    Keywords: type 2 diabetes

  • Cardiac structure and function in youth with type 2 diabetes in the iCARE cohort study: Cross-sectional associations with prenatal exposure to diabetes and metabolomic profiles

    Pediatric Diabetes

    Guillemette L, Dart A, Wicklow B, Dolinsky VW, Cheung D, Jassal DS, Sellers EAC, Gelinas J, Eves ND, Balshaw R, Agarwal P, Duhamel TA, Gordon JW, McGavock JM

    Research Project: iCARE

    Keywords: type 2 diabetes, Heart Disease, Pediatrics

  • An evaluation of renin-angiotensin system markers in youth with type 2 diabetes and associations with renal outcomes

    Pediatric Diabetes

    Dart AB, Wicklow B, Scholey J, Sellers EA, Dyck J, Mahmud F, Sochett E, Hamilton J, Blydt-Hansen T, Burns K

    Research Project: iCARE

    Keywords: type 2 diabetes

  • Urinary podocyte-derived microparticles in youth with type 1 and type 2 diabetes

    Diabetologia

    Sullivan KM, Scholey J, Moineddin R, Sochett E, Wicklow B, Elia Y, Xiao F, Mederios T, Sadi P, Burger D, Mahmud FH, Dart AB

    Research Project: iCARE,AdDIT

    Keywords: type 2 diabetes, Type 1 diabetes

  • Walking the path together: incorporating Indigenous knowledge in diabetes research

    The Lancet Diabetes & Endocrinology

    Maple-Brown LJ, Graham S, McKee J, Wicklow B.

    Research Project: iCARE

    Keywords: Indigenous Health, Diabetes

  • Comparison of Clinical and Social Characteristics of Canadian Youth Living with Type 2 and Type 1 Diabetes

    Canadian Journal of Diabetes

    Carino M, Elia Y, Sellers E, Curtis J, McGavock J, Scholey J, Hamilton J, Clarson C, Pinto T, Hadjiyannakis S, Mertens L, Samaan MC, Ho J, Nour M, Panagiotopoulos C, Jetha M, Gabbs M, Mahmud FH, Wicklow B, Dart A

    Research Project: iCARE,AdDIT

    Keywords: type 2 diabetes, Type 1 diabetes

  • Cardiovascular Comorbidity Associated With Albuminuria in Youth-Onset Type 2 Diabetes: Analyses From the iCARE Study

    Canadian Journal of Diabetes

    Sellers EAC, Dart AB, McGavock J, Wicklow BA

    Research Project: iCARE

    Keywords: Cardiovascular Disease, type 2 diabetes

  • Impact of COVID-19 Pandemic on Adolescents and Young Adults Living With Type 2 Diabetes

    Canadian Journal of Diabetes

    Marylin Carino, Zoe Quill, Melissa Gabbs, Elizabeth Sellers, Jill Hamilton, Teresa Pinto, Mary Jetha, Josephine, Onalee Garcia Alecio, Allison Dart, Brandy Wicklow

    Research Project: iCARE

    Keywords: type 2 diabetes, adolescents, COVID-19

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