Project Overview

One key function of the kidney is to balance the level of sodium in our bodies by getting rid of it through urine. There have been studies that show when kidney function is impaired, the extra sodium may end up on skin, muscle or bones, causing inflammation. There is a potential link between sodium and inflammation that may explain the symptoms that dialysis patients experience such as itch, low energy and restless legs. This study will try to examine sodium deposition in the skin, muscle and bones of patients with different kidney function and different dialysis modalities and its association with symptoms.

Evaluation of sodium deposition in soft tissues of patients with kidney disease and its association with patient symptomatology

Project lead(s):

Dr. Christopher McIntyre

Research theme(s):

Symptom Management

Project video

Visual Abstract

Click to view full size

Publications

  • Influence of Dialysate Sodium Prescription on Skin and Muscle Sodium Concentration

    American Journal of Kidney Diseases

    Lemoine S, Salerno FR, Akbari A, McIntyre CW

    Research Project: NaMRI

    Keywords: Dialysis, Sodium

  • Pruritus: Is there a grain of salty truth?

    Hemodialysis International

    Penny JD, Salerno FR, Akbari A, McIntyre CW

    Research Project: NaMRI

    Keywords: Dialysis, Sodium MRI

  • Tissue sodium concentrations in chronic kidney disease and dialysis patients by lower leg sodium-23 magnetic resonance imaging

    Nephrology Dialysis Transplantation

    Qirjazi E, Salerno FR, Akbari A, Hur L, Penny J, Scholl T, McIntyre CW

    Research Project: NaMRI

    Keywords: Dialysis, Sodium MRI

  • Tissue Sodium Storage in Patients With Heart Failure: A New Therapeutic Target?

    Circulation: Cardiovascular Imaging

    Lemoine S, Salerno FR, Akbari A, McKelvie RS, McIntyre CW

    Research Project: NaMRI

    Keywords: Cardiovascular Disease, Sodium, Glomerular Filtration Rate

  • Functional Sodium MRI Helps to Measure Corticomedullary Sodium Content in Normal and Diseased Human Kidneys

    Radiology

    Akbari A, Lemoine S, Salerno F, Marcus TL, Duffy T, Scholl TJ, Filler G, House AA, McIntyre CW

    Research Project: NaMRI

    Keywords: Chronic Kidney Disease, Sodium MRI

  • Management of severe polyuria in idiopathic Fanconi syndrome

    Pediatric Nephrology

    Filler G, Geda R, Salerno F, Zhang YC, de Ferris MED, McIntyre CW

    Research Project: NaMRI

    Keywords: Quality of Life, Polyuria, Fanconi Syndrome

  • Animal, Human, and 23Na MRI Imaging Evidence for the Negative Impact of High Dietary Salt in Children

    Current Pediatric Reports

    Filler G, Salerno F, McIntyre CW, de Ferris MED

    Research Project: NaMRI

    Keywords: Chronic Kidney Disease, Hypertension, Cardiovascular Disease

Connect with us!

Subscribe to receive updates from the Can-SOLVE CKD Network. Learn more about what we do, why it matters, and how you can get involved!