Can-SOLVE CKD Network Annual Meeting 2021 project video

Project lead: Dr. Michael Walsh
Patient lead: Gwen Herrington

Patients being treated with dialysis for end-stage kidney disease frequently suffer from symptoms like itchiness and restless legs. Despite how common these symptoms are, there is very little evidence about what the best treatments are. The DISCO Trials will explore whether promising treatments, some of which are already used in some patients, actually work. The first DISCO trial will identify whether two drugs, gabapentin and pramipexole, work alone or together to reduce the symptoms of restless legs in patients receiving dialysis.

Gabapentin and pramipexole are commonly used drugs for several conditions and are known to reduce restless legs in patients who do not have kidney disease. However, how restless legs develops in patients receiving dialysis is uncertain and likely differs from patients who do not have kidney disease and so whether these treatments also work in kidney disease is uncertain. Participants in DISCO will be randomly selected to either start taking gabapentin, pramipexole, both gabapentin and pramipexole, or to continue with their current treatments for at least 6 months. Participants will be asked about the frequency and severity of their restless leg symptoms and how the  impact their lives.

The results of DISCO will determine whether gabapentin, pramipexole, or both should be offered to patients receiving dialysis who suffer from restless legs. After we have completed the first DISCO trial, we will conduct further studies aimed at treatments for other symptoms (e.g. itch) and potentially other treatments for restless legs.

Can-SOLVE CKD Network Annual Meeting 2021 visual abstract

visual abstract PDF version