Better kidney health through patient-oriented research

The Can-SOLVE CKD research program comprises 18 multidisciplinary projects spanning basic science, clinical and population health research.

These projects are organized around three themes identified in collaboration with patients, health care providers, and policy-makers over three years of priority-setting discussions:

Together, the research projects will close existing gaps in kidney disease knowledge and care to deliver better health outcomes for patients. The Can-SOLVE CKD Network will achieve this ambitious vision through patient engagement and by integrating isolated pockets of basic, clinical and translational kidney research excellence across Canada.

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Defining risk and personalizing treatment of patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Genetic screening and tests of kidney size can help nephrologists identify high-risk patients for new or experimental treatments, moderate-risk patients for close surveillance, and low-risk patients for reassurance. These tests, however, are costly and not widely available. We will confirm the usefulness of these tests and make them less costly, allowing for increased use in clinics.


Clinical trials of promising re-purposed drugs for ADPKD

Advances in ADPKD research have identified a number of promising therapeutic drugs. Several of these drugs are re-purposed compounds that are currently approved for diseases other than ADPKD. We plan to perform two pilot control trials of two of these therapeutic drugs to test the impact on ADPKD patients and to evaluate their potential.


DISCO: Dialysis Symptom Control

Gabapentin and pramipexole are commonly used drugs for several conditions and are known to reduce restless legs in patients who do not have kidney disease. The results of DISCO will determine whether gabapentin, pramipexole, or both should be offered to patients receiving dialysis who suffer from restless legs.


EMPATHY: Patient-reported outcomes clustered RCT

Evidence suggests that patient-reported outcomes measures (PROMs) have a positive impact in clinical practice; however, the impact on health outcomes and experiences is not fully understood. This research aims to fill this gap by evaluating the impact of routinely measuring and reporting patient-reported experience and outcomes, clinical outcomes, and healthcare utilization.

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